Ever since the United States Drug Enforcement Administration was established in the early 1970's under President Nixon, their longtime mission has been to capture the nation's most notorious drug dealers in an effort to combat the "war on drugs." One of their methods has been to offer generous rewards to anyone who can help capture fugitives on their Most Wanted List, and sure enough, sometimes those rewards are in the multi-millions. 

As their website indicates today, the three fugitives who offer the highest rewards for capture are Dario Antonio Usuga David, Nemesio Oseguera-Cervantes,  and Rafael Caro-Quintero. 

Usuga David is said to be one of the leaders of El Clan Del Golfo, an extremely violent Colombian drug cartel comprised of former members of terrorist organizations. The organization uses violence and intimidation to control the narcotics throughout the country, while homicides reportedly shot up 443% over a two-year span during a turf war with a rival cartel. The reward for Usuga David's arrest is currently up to $5 Million.

Nemesio Oseguera Cervantes, who's commonly referred to as El Mencho, is an accused Mexican drug lord who's the leader of the Jalisco New Generation Cartel (CJNG), a criminal group based in Jalisco. For his role in coordinating drug trafficking operations, he is currently the most wanted criminal in Mexico, while one of the most wanted in the United States, with rewards of MXN$30 million and US$10 million respectively.

Rafael Caro-Quintero, is a suspected Mexican drug trafficker who co-founded the Guadalajara Cartel in the 1970's, and is allegedly responsible for the kidnapping and murders of DEA agent Enrique "Kiki" Camarena, Camarena's pilot Alfredo Zavala Avelar, the American writer John Clay Walker, and dentistry student Alberto Radelat in 1985. After the murders, Caro-Quintero fled to Costa Rica before he was extradited back to Mexico, where he was sentenced to 40 years for the murders. He was then freed from jail on August 9th, 2013, yet due to pressure from the federal government of the United States to re-arrest him, a Mexican federal court issued an arrest warrant a few days later. He remains a fugitive in Mexico and the United States, while the DEA is currently offering a $20 million bounty for his arrest.

Source: DEA