The human race's last hope, Alice (Milla Jovovich), awakens in the heart of Umbrella's most covert operations facility and discovers more of her mysterious past as she delves further into the complex. Without a safe haven, Alice continues to hunt down those responsible for the outbreak; a pursuit that takes her from Tokyo to New York, Washington, D.C. and Moscow, culminating in a shocking revelation that will force her to rethink everything that she once thought to be true.