Years past, during the rift between Game and 50, there were certain events that occurred that eventually led to the murder of Lowell "Lodi Mack" Fletcher, a former associate of 50 Cent.  

In March of 2007, 50 Cent, Tony Yayo, and Lodi Mack, got into an altercation with the son of James "Jimmy Henchman" Rosemond, of Czar Entertainment's (the label who managed Game at the time of the beef with 50).  Jimmy Henchman's son was eventually smacked in the face after being harassed by the crew.

Tony Yayo ended up receiving probation for the minor assault, while Lodi Mack ended up serving almost 2 years in prison for the smacking.  In September of 2009 in the Bronx, Lodi Mack was shot and killed just 2 weeks after his release from prison.  

James "Jimmy Henchman" Rosemond has recently been charged with ordering the hit. He is already incarcerated due to other serious allegation charges against him involving possession, and now he could potentially face the death penalty if convicted of the current murder charge.

Source: vibe.com