It has been revealed that Game's headlining single off of his upcoming F.I.V.E album will feature Lil Wayne and Chris Brown and it could be released as soon as Memorial Day Weekend.  His producer for the track, Sap, commented to XXL about the upcoming single.

"I actually produced this record for Game called 'F.I.V.E.,' featuring Chris Brown and Lil Wayne. That should be dropping anytime now. Supposedly it's dropping Memorial Day Weekend, but I'm not sure. It's definitely got an East Coast style a little bit—it kind of reminds you of how that 'Real' joint is. It's not a South beat. It's more of an up tempo beat, but it's not a club record. It's more of a traditional hip-hop beat, like a hard sample. It's Game's style but it's still something you can hear Wayne on, too."

Source: hiphop-n-more.com